BICOMIDE® The daily solution for acne-prone skin
It is estimated that all adolescents will be affected by acne vulgaris in some stage of their life. However, sometimes this condition persists into adulthood. Acne is the most prevalent dermatologic condition worldwide (Hay RJ et al 2010) and its complications can lie into complex symptoms. While acne origin is complex, is well accepted that the development of acne lesions starts with the obstruction of the pilosebaceus canals because of the accumulation of keratinized cells and increase of sebum production. In this environment it becomes easy the proliferation of the anaerobic bacterium Propionibacterium acnes (P. acnes). Current treatments include the use of molecules that help unclog pores, control surface bacteria and stimulate skin renewal. Although most treatments help reduce acne, they have compliance issues as they often cause skin dryness and irritation. Bicosome is a double encapsulation delivery system formed by intelligent structures able to recognize and respond to the different skin layers. Bicosomes can incorporate and deliver active ingredients directly in the skin layers where they need to work, allowing for the reduction of active ingredient concentration.
In this study we evaluated the effectiveness of a sophisticated system, Bicomide, which combines Bicosomes and Niacinamide. Niacinamide is usually indicated in concentrations of 2- 4% (Z. Draelos et al 2006). In this work, Niacinamide was incorporated in Bicosomes and formulated in a gel with a final concentration of 0.3%.
The in vivo study with 20 volunteers shows that after 30 days of treatment, Bicomide had a sebostatic effect, reducing around 25% of the amount of sebum and a direct antimicrobial effect, reducing 24% of the Porphyrin size area. These results were achieved with around 10 times less concentration of Niacinamide than usual, which evidences the efficacy of the Bicosomes to deliver the active ingredient in the target skin layers, boosting its efficacy.
- Rosana Saldana LCM
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